{"id":3255,"date":"2014-11-28T12:46:46","date_gmt":"2014-11-28T10:46:46","guid":{"rendered":"https:\/\/ivoxen.wpstk.com\/?p=3255"},"modified":"2022-09-14T13:28:48","modified_gmt":"2022-09-14T13:28:48","slug":"embryo-glue-ivf-success","status":"publish","type":"post","link":"https:\/\/ivoxivf.com\/tr\/embryo-glue-ivf-success\/","title":{"rendered":"Embriyo yap\u0131\u015ft\u0131r\u0131c\u0131 ivf ba\u015far\u0131s\u0131"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"3255\" class=\"elementor elementor-3255\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-37445cd6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"37445cd6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70e965c1\" data-id=\"70e965c1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e823fc5 elementor-widget elementor-widget-image\" data-id=\"e823fc5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/ivoxivf.com\/wp-content\/uploads\/2014\/11\/1x1.png\" class=\"attachment-large size-large wp-image-34546\" alt=\"embriyo yap\u0131\u015ft\u0131r\u0131c\u0131 t\u00fcp bebek ba\u015far\u0131s\u0131\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-225404c5 elementor-widget elementor-widget-text-editor\" data-id=\"225404c5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Embriyo Yap\u0131\u015ft\u0131r\u0131c\u0131 ivf ba\u015far\u0131s\u0131<\/h2><p>kullan\u0131lan bir k\u00fclt\u00fcr ortam\u0131d\u0131r. <a href=\"\/tr\/embryo-transfer\/\">embriyo transferi<\/a>. Hyaluronan adl\u0131 i\u00e7erik maddesinin etkisi ile embriyonun rahim i\u00e7ine yap\u0131\u015fma \u015fans\u0131 artar.<\/p><h2><span style=\"color: #3fa389;\">Embriyo Yap\u0131\u015ft\u0131r\u0131c\u0131 Nedir?<\/span><\/h2><p class=\"\">\u0130lk t\u00fcp bebek uygulamalar\u0131ndan ba\u015flayan zaman i\u00e7erisinde tedavideki ba\u015far\u0131 giderek artmaktad\u0131r. Uygulaman\u0131n ilk y\u0131llar\u0131nda y\u00fczde 10-15&#039;lik ba\u015far\u0131 oran\u0131n\u0131n g\u00fcn\u00fcm\u00fczde y\u00fczde 50-60&#039;lara ula\u015fm\u0131\u015f olmas\u0131 \u00e7ok sevindirici. Bu art\u0131\u015fta en \u00f6nemli rol, embriyolar\u0131n laboratuvar ortam\u0131nda b\u00fcy\u00fct\u00fclmesi ile ilgili geli\u015fmedir. In vitro fertilizasyon uygulamas\u0131nda embriyolar anne v\u00fccudu yerine laboratuvar ortam\u0131nda birle\u015ftirilir ve embriyolar anne rahmindeki ayn\u0131 geli\u015fmeleri taklit eden \u00f6zel s\u0131v\u0131lar i\u00e7inde b\u00fcy\u00fct\u00fcl\u00fcr. T\u00fcp bebek uygulamalar\u0131nda tedavinin verimini s\u0131n\u0131rlayan \u00f6nemli hususlardan biridir. Laboratuvar ko\u015fullar\u0131 hi\u00e7bir zaman anne v\u00fccudunun \u00f6zelliklerini tam olarak taklit edemezdi. Ancak laboratuvar ko\u015fullar\u0131ndaki geli\u015fmeler bu benzerli\u011fi her ge\u00e7en g\u00fcn artt\u0131rmakta ve bu da tedavideki ba\u015far\u0131y\u0131 do\u011frudan etkilemektedir.<\/p><p><span style=\"text-decoration: underline;\"><strong>&quot;Embriyo Yap\u0131\u015ft\u0131r\u0131c\u0131&quot;,<\/strong><\/span> \u00f6zel bir k\u00fclt\u00fcr ortam\u0131n\u0131n ticari ad\u0131 olarak piyasada yer alacakt\u0131r. Bu k\u00fclt\u00fcr ortam\u0131, embriyolar\u0131n rahim i\u00e7ine transferi s\u0131ras\u0131nda, embriyolar\u0131 kateter i\u00e7inde bar\u0131nd\u0131ran ve bu embriyolar\u0131 rahim i\u00e7ine ta\u015f\u0131yan s\u0131v\u0131d\u0131r. Bu s\u0131v\u0131n\u0131n \u00f6zelli\u011fi \"hyaluronan\" ad\u0131 verilen bir maddedir. Embriyo transferi s\u0131ras\u0131nda bu maddenin k\u00fclt\u00fcr s\u0131v\u0131s\u0131na eklenmesinin embriyolar\u0131n rahim i\u00e7inde tutunmas\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclmektedir.<\/p><p>Embriyolar\u0131n transferi s\u0131ras\u0131nda bu zamana kadar embriyolar\u0131n 3 veya 5 g\u00fcn boyunca i\u00e7inde b\u00fcy\u00fct\u00fclece\u011fi ve laboratuvar ortam\u0131nda embriyolar\u0131n geli\u015ftirilmesi i\u00e7in haz\u0131rlanan bir k\u00fclt\u00fcr s\u0131v\u0131s\u0131 kullan\u0131lmaktayd\u0131. Bundan sonraki transfer k\u00fclt\u00fcr ortam\u0131, embriyolar\u0131n laboratuvar ortam\u0131nda geli\u015ftirilmesi i\u00e7in kullan\u0131lan s\u0131v\u0131dan baz\u0131 farkl\u0131 \u00f6zellikler i\u00e7ermektedir. En \u00f6nemli fark, s\u0131v\u0131n\u0131n i\u00e7indeki hyaluronan maddesidir. Hyaluronan, t\u0131bb\u0131n di\u011fer bir\u00e7ok dal\u0131nda da kan\u0131tlanm\u0131\u015f bir maddedir ve h\u00fccreler aras\u0131ndaki ba\u011f\u0131n ve h\u00fccrelerin ay\u0131rt edici \u00f6zelliklerinin belirlenmesinde \u00f6nemli rol oynar. Bu maddenin embriyo-endometrium ili\u015fkisi \u00fczerindeki etkisi hala bilinmemektedir. Belirlenen neden, bu maddenin embriyonun rahim i\u00e7inde yap\u0131\u015fma \u015fans\u0131n\u0131 artt\u0131rmas\u0131d\u0131r. <strong>embriyo tutkal\u0131<\/strong>\u00a0maddenin \u015fu yollarla etkisini artt\u0131rd\u0131\u011f\u0131 ileri s\u00fcr\u00fclebilir:<\/p><ul><li>1. Hyaluronan, h\u00fccreler ve h\u00fccre-doku aras\u0131ndaki ba\u011flar\u0131 g\u00fc\u00e7lendirir.<\/li><li>2. Hyaluronan vask\u00fclarizasyonu uyarma \u00f6zelli\u011fine sahiptir.<\/li><li>3. Yeti\u015ftirme s\u0131v\u0131s\u0131na hyaluronan eklenmesi viskoziteyi azaltabilir. Bu \u015fekilde rahim i\u00e7ine daha fazla viskoz-viskoz enjekte edilmedi\u011finden embriyonun yap\u0131\u015fma \u015fans\u0131n\u0131n artt\u0131\u011f\u0131 iddia edilmektedir.<\/li><\/ul><p>\u00a0<\/p><p>Hyaluronan i\u00e7eren transfer ortam\u0131 ile ger\u00e7ekle\u015ftirilen tek bir \u00e7al\u0131\u015fma vard\u0131r. Bu \u00e7al\u0131\u015fma 2002 y\u0131l\u0131nda American Society of Reproductive Medicine toplant\u0131s\u0131nda sunulmu\u015ftur. Bu \u00e7al\u0131\u015fmada 73 hastada hyaluronan i\u00e7eren transfer k\u00fclt\u00fcr ortam\u0131, 68 hastada ise klasik transfer ortam\u0131 kullan\u0131lm\u0131\u015ft\u0131r. Klasik transfer ortam\u0131nda y\u00fczde 21.7 olan embriyo ba\u015f\u0131na tutunma \u015fans\u0131 (implantasyon oran\u0131) hyaluronan grubunda y\u00fczde 45.8'e y\u00fckselmi\u015ftir. Benzer \u015fekilde gebelik oranlar\u0131 da y\u00fczde 48,5'ten y\u00fczde 58,9'a y\u00fckselmektedir.<\/p><p>T\u00fcp bebek tedavisinde ba\u015far\u0131 oran\u0131 sadece embriyo k\u00fclt\u00fcr ortam\u0131 ile ilgili de\u011fildir. Tedavide ba\u015far\u0131 oran\u0131n\u0131 etkileyen bir\u00e7ok fakt\u00f6r vard\u0131r. Laboratuvarda durma noktalar\u0131 oldu\u011fu i\u00e7in bozuk bir yap\u0131da ve hatal\u0131 bir sistemde hi\u00e7bir de\u011fi\u015fiklik yapmadan sadece ekim ortam\u0131n\u0131 yenilemek; yeni k\u00fclt\u00fcr ortam\u0131 kullanmak ba\u015far\u0131 oran\u0131na katk\u0131 sa\u011flamayacakt\u0131r. Tedavi sonras\u0131 ba\u015far\u0131, ideal olarak klinik ve laboratuvardan olu\u015fan iki ayr\u0131 sistemin birle\u015ftirilmesi ile sa\u011flanabilir. Klinik taraf\u0131ndan laboratuvara etkin olmayan bir materyal g\u00f6nderildi\u011finde, hangi k\u00fclt\u00fcr ortam\u0131 kullan\u0131l\u0131rsa kullan\u0131ls\u0131n bu materyalden y\u00fcksek kaliteli embriyolar elde etmek \u00e7ok zor olacakt\u0131r. Ba\u015far\u0131s\u0131z bir tedavinin ard\u0131ndan bir\u00e7ok husus g\u00f6zden ge\u00e7irilmelidir. Tedavide \u00f6nemli noktalardan biri y\u00fcksek kalitede yumurta \u00fcretiminin sa\u011flanmas\u0131d\u0131r. Bu noktada uygun ila\u00e7 protokol\u00fc ve dozu se\u00e7ilmeli, yumurta geli\u015fiminin takibi do\u011fru ve \u00f6zenli bir \u015fekilde s\u00fcrd\u00fcr\u00fclmeli, hCG zaman\u0131nda enjekte edilmeli, yumurta toplama ve embriyo transfer i\u015flemleri do\u011fru bir \u015fekilde ger\u00e7ekle\u015ftirilmelidir. Dikkatsiz ve geli\u015fig\u00fczel yap\u0131lan tedavilerde laboratuvar tekniklerinin yenilenmesi amaca hizmet etmeyecektir.<\/p><p><strong><u>embriyo tutkal\u0131<\/u><\/strong> ne bir teknik ne de bir operasyondur. Embriyolar rahim i\u00e7 duvarlar\u0131na yap\u0131\u015fmayacakt\u0131r. Embriyo (e\u011fer sa\u011fl\u0131kl\u0131 ise) ba\u011flanma eylemini kendili\u011finden ger\u00e7ekle\u015ftirecektir. Yap\u0131\u015fma potansiyeli olmayan bir embriyo, herhangi bir i\u015flem veya madde ile rahim i\u00e7 duvarlar\u0131na (en az\u0131ndan \u015fimdilik veya yak\u0131n gelecekte) yap\u0131\u015fmayacakt\u0131r. Embriyonun i\u00e7 duvarlara yap\u0131\u015fmas\u0131 hala bir gizemdir. Tek bildi\u011fimiz bu d\u00f6nemde rahim i\u00e7inde baz\u0131 maddelerin salg\u0131lanmas\u0131n\u0131n artt\u0131\u011f\u0131 ya da embriyonun baz\u0131 maddelerin eksikli\u011finde ba\u011flanma eyleminin ger\u00e7ekle\u015fmedi\u011fi. Bilim bu dolayl\u0131 bilgiyi tedavinin etkinli\u011fini art\u0131rmak i\u00e7in kullan\u0131yor. Hyaluronan veya yukar\u0131da bahsetti\u011fimiz \"L\u00f6semi inhibit\u00f6r fakt\u00f6r (LIF)\" bunlara \u00f6rnektir. Biz bu konuda neden-sonu\u00e7 ili\u015fkisi kurmad\u0131\u011f\u0131m\u0131z i\u00e7in sadece olas\u0131 eksiklikleri telafi ederek \u015fans\u0131m\u0131z\u0131 art\u0131rmaya \u00e7al\u0131\u015f\u0131yoruz. Dolay\u0131s\u0131yla hyaluronan katk\u0131l\u0131 k\u00fclt\u00fcr ortamlar\u0131 ile ger\u00e7ekle\u015ftirilen transferler t\u00fcp bebek uygulamalar\u0131nda ba\u015far\u0131 oran\u0131n\u0131 y\u00fczde 100'e \u00e7\u0131karmayacakt\u0131r. Belki belirli bir hasta grubunda etkili olacak ve t\u00fcm hastalara yard\u0131mc\u0131 olmayacakt\u0131r. Ama ba\u015far\u0131 oran\u0131n\u0131 y\u00fczde 1 veya 5 art\u0131rabilecek her t\u00fcrl\u00fc geli\u015fme bizim i\u00e7in \u00e7ok \u015fey ifade edecektir.<\/p><p>Hyaluronan ile zenginle\u015ftirilmi\u015f embriyo transfer k\u00fclt\u00fcr ortam\u0131 s\u0131n\u0131rl\u0131 say\u0131da \u00e7al\u0131\u015fmada kullan\u0131lm\u0131\u015ft\u0131r. <a href=\"\/tr\/in-vitro-fertilization\/\">T\u00fcp bebek <\/a>d\u00fcnya \u00e7ap\u0131nda merkezler. K\u00fclt\u00fcr ortam\u0131n\u0131n 4-6 ay i\u00e7inde t\u00fcm IVF merkezleri i\u00e7in piyasaya s\u00fcr\u00fclmesi beklenmektedir. Dolay\u0131s\u0131yla, bu yeni k\u00fclt\u00fcr besiyeri hakk\u0131ndaki bilgiler \u00e7ok s\u0131n\u0131rl\u0131d\u0131r.<\/p><p>\u00a0<\/p><p>[shortcode_carousel title='Embriyo Tutkal Resimleri]<\/p><p><\/p><p>[\/shortcode_carousel]<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Embryo Glue ivf ba\u015far\u0131s\u0131 embriyo transferinde kullan\u0131lan bir k\u00fclt\u00fcr besiyeridir. Hyaluronan adl\u0131 i\u00e7erik maddesinin etkisi ile embriyonun rahim i\u00e7ine yap\u0131\u015fma \u015fans\u0131 artar.<\/p>","protected":false},"author":1,"featured_media":26462,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[20],"tags":[89,90,91],"class_list":["post-3255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivf","tag-embriyo-glue","tag-embryo-glue-ivf-success","tag-embryo-glue-success"],"_links":{"self":[{"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/posts\/3255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/comments?post=3255"}],"version-history":[{"count":0,"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/posts\/3255\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/media\/26462"}],"wp:attachment":[{"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/media?parent=3255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/categories?post=3255"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ivoxivf.com\/tr\/wp-json\/wp\/v2\/tags?post=3255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}